Skip to content
Search

Latest Stories

High salt intake causes cognitive impairment linked to hypertension, study finds

The hormone Angiotensin II (Ang II) and its receptor “AT1” are recognized for their crucial role in regulating blood pressure and fluid balance

High salt intake causes cognitive impairment linked to hypertension, study finds

Researchers have discovered a correlation between hypertension, resulting from high salt intake, and emotional and cognitive dysfunction according to a recent study conducted by Fujita Health University in Japan.

The study reveals that excessive consumption of table salt, a commonly used food seasoning, has been associated with cognitive impairment.


Additionally, it is well-established that high salt intake is a contributing factor to the development of hypertension.

The study further explains that the mechanism behind this link involves disrupted signalling between the blood pressure regulation system and specific lipid molecules in the brain, ultimately leading to dysfunction.

The hormone Angiotensin II (Ang II) and its receptor "AT1" are recognized for their crucial role in regulating blood pressure and fluid balance.

Previous research has established the connection between Ang II-AT1 and the physiologically significant lipid molecule prostaglandin E2 (PGE2) and its receptor "EP1" in relation to hypertension and neurotoxicity.

However, the precise involvement of these systems in hypertension caused by high salt intake (HS) and its impact on emotional and cognitive functioning has remained unclear.

The recent study, published in the British Journal of Pharmacology, sheds light on this matter by demonstrating how the crosstalk between Ang II-AT1 and PGE2-EP1 contributes to HS-mediated hypertension and subsequent emotional and cognitive dysfunction.

"Excessive salt intake is considered a risk factor for hypertension, cognitive dysfunction, and dementia. However, studies focusing on the interaction between the peripheral and central nervous system have not sufficiently investigated this association," said author Hisayoshi Kubota from the university's Graduate School of Health Science.

The study observed that in mice, the emotional and cognitive effects were mainly attributed to tau phosphorylation, which refers to the excessive addition of phosphates to the protein called "tau."

Tau is a crucial protein associated with Alzheimer's disease.

During the study, the researchers administered a high-salt (HS) solution (consisting of 2% sodium chloride in drinking water) to laboratory mice for a duration of 12 weeks while closely monitoring their blood pressure.

"The effects of HS intake on emotional/cognitive function and tau phosphorylation were also examined in two key areas of the mouse brain - the prefrontal cortex and the hippocampus," explained Akihiro Mouri, professor at the university's School of Health Sciences.

Additionally, the researchers investigated the role of the Ang II-AT1 and PGE2-EP1 systems in high-salt (HS) induced hypertension and neuronal/behavioural impairment. The study revealed several biochemical changes in the brains of the mice.

Apart from tau phosphorylation, the researchers observed a reduction in the phosphate groups associated with a crucial enzyme called "CaMKII" at the molecular level. CaMKII is a protein involved in signalling processes in the brain.

Moreover, they detected alterations in the levels of "PSD95," a critical protein responsible for organizing and facilitating the connections between brain cells, known as synapses.

Interestingly, all these biochemical changes were observed to be reversed when the mice were administered the antihypertensive drug "losartan."

Similarly, the researchers noted a comparable reversal when the EP1 gene was knocked out.

The findings of the study indicate that the angiotensin II-AT1 and prostaglandin E2-EP1 systems could serve as promising targets for therapeutic interventions against dementia induced by hypertension.

In order to mitigate potential health risks, the World Health Organization advises restricting daily salt intake to less than 5 grams.

(PTI)

More For You

Reconnecting with lost Eid traditions

Bring the past into the present for a richer celebration

Reconnecting with lost Eid traditions

EID is a joyous time filled with unity, reflection, and celebration.

While the essence of the celebration has remained unchanged across centuries, the way this special day is celebrated has evolved, with many older traditions being replaced by modern practices and technological advancements.

Keep ReadingShow less
Reconnecting with lost Eid traditions: Bringing meaning back to modern celebrations

Eid offers new ways to mark the occasion

Reconnecting with lost Eid traditions: Bringing meaning back to modern celebrations

REVIVING OLD CUSTOMS CAN ADD MORE MEANING TO FESTIVALS Reconnecting with lost Eid traditions EID celebrations have evolved over time, beautifully blending tradition with modernity. While many older practices remain, new ways of celebrating the special day, influenced by technology and changing lifestyles, are keeping the spirit of Eid alive in a more globalised world. Here are some newer customs that have been fully embraced by modern society in a positive way.

Virtual: In the past, the only way to connect with loved ones far away was through long-distance phone calls, which were limited due to their high cost. Now, Zoom gatherings allow many people from around the world to connect at once.

Keep ReadingShow less
Top 5 luxury hotels for an opulent Ramadan stay

From Dubai’s iconic Burj Al Arab to Geneva’s ultra-exclusive Hotel President Wilson, these breath-taking destinations redefine opulence with gourmet Iftars, private Suhoors, and five-star hospitality

iStock

Top 5 luxury hotels for an opulent Ramadan stay in 2025

As the crescent moon signals the arrival of Ramadan, the world's most prestigious hotels bring us experiences that merges spiritual reflection with luxury. For discerning travellers looking to just upgrade their holy month, these five iconic properties offer not just the Iftar experiences but also, memories woven with gold threads of opulence.

1.Burj Al Arab Jumeirah, Dubai - Seven-star dreams meet Ramadan traditions

Keep ReadingShow less
Why Do Muslims Celebrate Eid al-Fitr on Different Days? 3 Key Reasons

Some may celebrate on one day, while others may observe it the next

iStock

3 reasons why Muslims across the globe celebrate Eid al-Fitr on different days

Eid is one of the most joyous and important festivals in Islam, celebrated twice a year by Muslims worldwide. However, it’s common to see variations in the exact day of celebration, even within the same country. Some may celebrate on one day, while others may observe it the next. This divergence can sometimes confuse people outside the Muslim community and even among Muslims themselves. But the reasons for this variation are rooted in Islamic traditions and differing interpretations of how to determine the Islamic calendar.

Here are the three main reasons why Muslims don’t always celebrate Eid on the same day:

Keep ReadingShow less
Ranvir Singh Talks About Relationship with Louis Church

For Ranvir, the journey of love and parenthood continues

Getty

GMB's Ranvir Singh shares insight into relationship with younger boyfriend Louis Church

Ranvir Singh, the popular presenter of Good Morning Britain (GMB), has recently offered a rare glimpse into her relationship with her younger partner, Louis Church. Despite being one of the most recognisable faces on UK television, Ranvir, 47, has generally kept her personal life private. However, in recent interviews, she has opened up about her relationship with the 29-year-old TV production manager and how he fits into her life, especially with her 13-year-old son, Tushaan.

Ranvir's past: A single mother and new beginnings

Ranvir Singh's journey as a single mother has been a central part of her life story. She was married to Ranjeet Singh Dehal, with whom she tied the knot in 2012. The couple welcomed their son Tushaan later that year. However, after some years, the marriage ended quietly, and it wasn’t until much later that Ranvir confirmed her single status.

Keep ReadingShow less