Skip to content
Search

Latest Stories

Mouth bacteria linked to colon cancer growth, says study

This bacterium, commonly found in the mouth, was detected within the tumours of roughly half of the 200 colon cancer patients examined.

Mouth bacteria linked to colon cancer growth, says study

Colon cancer, also known as colorectal cancer, remains a leading cause of morbidity and mortality worldwide. While some risk factors are well-established, such as diet and lifestyle choices, the exact causes of colon cancer are complex and not fully understood.

A recent groundbreaking study published in the journal Nature has shed light on a potential new player in this equation: a common mouth bacterium called Fusobacterium nucleatum.


The study, conducted by researchers at the Fred Hutch Cancer Center in the US, revealed a surprising link between a specific subtype of Fusobacterium nucleatum and the presence and progression of colon cancer. This bacterium, commonly found in the mouth, was detected within the tumours of roughly half of the 200 colon cancer patients examined.

Notably, the presence of this bacteria was associated with poorer patient outcomes, suggesting a potential role in promoting cancer growth and hindering treatment efficacy.

The researchers, led by co-corresponding author Susan Bullman, delved deeper to understand the mechanism behind this connection. Fusobacterium nucleatum is not typically found in the colon, raising the question of how it migrates from its usual habitat in the mouth to the distant location of the lower gut.

The study revealed a key finding: the specific subtype identified within the tumours, designated Fna C2, possessed distinct genetic variations compared to its mouth-dwelling counterparts. These variations suggest an adaptation for survival within the harsh acidic environment of the stomach, allowing the bacteria to make the journey from mouth to colon.

Further investigation revealed a higher prevalence of Fna C2 in stool samples of colon cancer patients compared to healthy individuals. This suggests that the bacteria not only manages to establish itself within the colon but also potentially contributes to the development of the cancerous environment.

The exact mechanisms by which Fna C2 promotes colon cancer growth remain under investigation. However, some theories have emerged. The bacteria may produce enzymes that damage host cells, creating a pro-inflammatory environment conducive to tumour formation. Additionally, Fna C2 could potentially shield cancer cells from the effects of chemotherapy drugs, leading to poorer treatment outcomes.

The implications of this research are significant. Identifying Fna C2 as a potential culprit in colon cancer development opens new avenues for treatment strategies. Therapies targeting this specific bacterial strain or its interactions with cancer cells could be explored. Additionally, the presence of Fna C2 in stool samples offers the potential for a non-invasive screening method for early detection of colon cancer.

Beyond the immediate findings, this research talks about the complex interplay between the human microbiome and various diseases. The human body harbours trillions of microorganisms, and their role in health and disease is becoming increasingly recognised. Understanding how specific microbes like Fna C2 interact with our systems offers valuable insights for preventative and therapeutic approaches.

However, further research is necessary to solidify these findings. Larger clinical studies are needed to confirm the association between Fna C2 and colon cancer across diverse populations. Additionally, a deeper understanding of the mechanisms employed by Fna C2 to promote cancer growth is crucial for developing targeted therapies.

The discovery of a link between Fusobacterium nucleatum and colon cancer is a significant step forward in our understanding of this complex disease.

More For You

Sukhvinder Kaur: Finding light in the tunnel of loneliness

Sukhvinder Kaur: Finding light in the tunnel of loneliness

LONELINESS can affect people of all ages and backgrounds in different ways. Sukhvinder Kaur was deeply impacted by social isolation after her marriage broke down, leaving her alone with two young children.

Despite a happy upbringing, a supportive family, and a strong community network, she began experiencing uncomfortable thoughts that didn’t resonate with her, leading to increased isolation.

Keep ReadingShow less
Ayurveda: The ancient science of balance and well-being

Ayurveda was given to mankind at the time of satyug, when the diseases though existed had not yet manifested in the physical world.

iStock

Ayurveda: The ancient science of balance and well-being

Ashwini Gurujii

Ayurveda finds it origin in one of the four Vedas, the Atharvaveda. Brahma ji propounded the science of Ayurveda and passed it on to Daksh Prajapati, who gave it to Ashwini Kumars, the physicians of devas, and they gave it to Indra.

Ayurveda was given to mankind at the time of satyug, when the diseases though existed had not yet manifested in the physical world. The level of existence was so pure and selfless that diseases were unable to manifest then. The rishis of satyug realized that in the times to come, the thoughts of people are going to become so polluted that diseases will find the required environment to manifest and then the need of Ayurveda would arise, so Rishi Bharadwaj went up to Indra Dev and asked for this divine science.

Keep ReadingShow less
Why helping ageing parents is precious

As our parents age, we embrace new roles in their lives with compassion and care.

Why helping ageing parents is precious

AS OUR parents’ health begins to deteriorate, one of the hardest things in life is watching them age. Some can no longer walk for more than 10 minutes, and their memory isn’t what it used to be. There are also hidden complications associated with ageing.

I grew up in a working-class family. My dad was named Simba when he lived back in Zanzibar, Africa. He swam in the open ocean and ran for miles. The joinery skills he learned from his father have been passed down to my brother and me. My mum worked long hours sewing and in factories to provide for us, ensuring we had everything we needed. She also taught me never to rely on anyone for anything, which has shaped me into the strong, independent woman I am today.

Keep ReadingShow less
Spring-clock-change-iStock

Circadian rhythms regulate physiological processes in living organisms, including plants, animals, and even bacteria. (Photo: iStock)

How the spring clock change impacts sleep and health

EVERY YEAR, about a quarter of the world's population adjusts their clocks for daylight saving time (DST).

While it may seem like a small change, some experience fatigue, irritability, and brain fog in the days that follow. For night owls, the adjustment can take weeks.

Keep ReadingShow less
Reconnecting with lost Eid traditions

Bring the past into the present for a richer celebration

Reconnecting with lost Eid traditions

EID is a joyous time filled with unity, reflection, and celebration.

While the essence of the celebration has remained unchanged across centuries, the way this special day is celebrated has evolved, with many older traditions being replaced by modern practices and technological advancements.

Keep ReadingShow less