Skip to content
Search

Latest Stories

Obesity is a neurodevelopmental disorder, propose scientists

The team reports in the journal Science Advances that molecular mechanisms of brain development during early life are likely a major determinant of obesity risk.

Obesity is a neurodevelopmental disorder, propose scientists

Obesity has increased rapidly in recent decades to affect more than 2 billion people, making it one of the largest contributors to poor health worldwide. Despite decades of research on diet and exercise treatments, many people continue to struggle to lose weight. Researchers at Baylor College of Medicine and collaborating institutions now think they know why, and say we must shift the focus from obesity treatment to prevention.

The team reports in the journal Science Advances that molecular mechanisms of brain development during early life are likely a major determinant of obesity risk. Previous large studies in humans have hinted that genes that are most strongly associated with obesity are expressed in the developing brain. This current study in mice focused on epigenetic development. Epigenetics is a system of molecular bookmarking that determines which genes will, or will not, be used in different cell types.


"Decades of research in humans and animal models have shown that environmental influences during critical periods of development have a major long-term impact on health and disease," said corresponding author Dr. Robert Waterland, professor of pediatrics-nutrition and a member of the USDA Children's Nutrition Research Center at Baylor. "Body weight regulation is very sensitive to such 'developmental programming,' but exactly how this works remains unknown."

"In this study, we focused on a brain region called the arcuate nucleus of the hypothalamus, which is a master regulator of food intake, physical activity and metabolism," said first author Dr. Harry MacKay, who was a postdoctoral associate in the Waterland lab while working on the project. "We discovered that the arcuate nucleus undergoes extensive epigenetic maturation during early postnatal life. This period is also exquisitely sensitive to developmental programming of body weight regulation, suggesting that these effects could be a consequence of dysregulated epigenetic maturation."

The team conducted genome-wide analyses of both DNA methylation - an important epigenetic tag - and gene expression, both before and after the closure of the postnatal critical window for developmental programming of body weight.

"One of our study's biggest strengths is that we studied the two major classes of brain cells, neurons and glia," MacKays said. "It turns out that epigenetic maturation is very different between these two cell types."

"Our study is the first to compare this epigenetic development in males and females," Waterland said. "We were surprised to find extensive sex differences. In fact, in terms of these postnatal epigenetic changes, males and females are more different than they are similar. And, many of the changes occurred earlier in females than in males, indicating that females are precocious in this regard."

(ANI)

More For You

Pahalgam attack: Prayer meet held at Indian mission in London

The prayer meet was led by Indian High Commissioner to the UK Vikram Doraiswami

Pahalgam attack: Prayer meet held at Indian mission in London

A PRAYER meet was held at the Gandhi Hall in the High Commission of India in London on Thursday (24) to pay respects to the victims of the Pahalgam terrorist attack.

Chants of ‘Bharat Mata Ki Jai’ rang out at the event which was led by Indian High Commissioner to the UK Vikram Doraiswami.

Keep ReadingShow less
UK  mini heatwave

Sunny conditions will bring early summer warmth

Getty

UK to see mini heatwave as temperatures climb towards 24 °c

The UK is set for a period of warmer weather in the coming days, with temperatures expected to rise significantly across parts of the country. According to the Met Office, a spell of dry and sunny conditions will bring early summer warmth, although it will fall short of the threshold for an official heatwave.

Temperatures in south-eastern and central England could reach 23°c to 24°c by Tuesday, around 10C above the seasonal average for some areas. The Met Office described this as a “very warm spell” rather than a heatwave, though the contrast with recent cooler weather will be noticeable.

Keep ReadingShow less
indian-army-reuters

Indian security force personnel stand guard at the site of the attack on tourists in Baisaran near Pahalgam in south Kashmir's Anantnag district, April 24, 2025. (Photo: Getty Images)

Getty Images

Indian and Pakistani troops exchange fire along Line of Control

INDIAN and Pakistani troops exchanged fire overnight along the Line of Control in Kashmir, officials from both sides said on Friday.

The exchange took place days after a deadly attack in the region and amid calls from the United Nations for both countries to show "maximum restraint".

Keep ReadingShow less
India declares state mourning for Pope Francis, Modi leads tributes

A sculpture by Indian sand artist Sudarsan Pattnaik in Puri, Odisha, on Monday (21)

India declares state mourning for Pope Francis, Modi leads tributes

INDIA began three days of state mourning on Tuesday (22) for the Pope, a rare honour for a foreign religious leader, as prime minister Narendra Modi joined other south Asian and world leaders in paying tributes following his death on Monday (21).

Pope Francis, the 88-year-old leader of 1.4 billion Catholics across the world, died of a stroke, causing a coma and “irreversible” heart failure, the Vatican said.

Keep ReadingShow less
Minority youth face racist content online once a week, report reveals

As many as 95 per cent of respondents reported encountering violent or abusive racist content online. (Photo: iStock)

Minority youth face racist content online once a week, report reveals

MOST young people from black and minority communities in Britain encounter racist content online, a new study revealed, with more than half reporting it damages their sense of safety.

The "Youth, Race and Social Media" report published on Thursday (24) highlighted a troubling picture of online racism and its effects on young people aged 16-24.

Keep ReadingShow less