Smoking raises risk of midlife memory loss, confusion
It’s also one more piece of evidence that quitting smoking is good not just for respiratory and cardiovascular reasons – but to preserve neurological health, said Rajczyk, a PhD student in Ohio State’s College of Public Health, and senior author Jeffrey Wing, assistant professor of epidemiology.
According to a new study, middle-aged smokers are considerably more likely than nonsmokers to experience memory loss and confusion, and the chance of cognitive decline is lower for those who have quit smoking recently.
The research by The Ohio State University is the first to examine the relationship between smoking and cognitive decline using a one-question self-assessment asking people if they've experienced worsening or more frequent memory loss and/or confusion. The findings build on previous research that established relationships between smoking and Alzheimer's Disease and other forms of dementia, and could point to an opportunity to identify signs of trouble earlier in life, said Jenna Rajczyk, lead author of the study, which appears in the Journal of Alzheimer's Disease.
It's also one more piece of evidence that quitting smoking is good not just for respiratory and cardiovascular reasons - but to preserve neurological health, said Rajczyk, a PhD student in Ohio State's College of Public Health, and senior author Jeffrey Wing, assistant professor of epidemiology.
"The association we saw was most significant in the 45-59 age group, suggesting that quitting at that stage of life may have a benefit for cognitive health," Wing said. A similar difference wasn't found in the oldest group in the study, which could mean that quitting earlier affords people greater benefits, he said.
Data for the study came from the national 2019 Behavioral Risk Factor Surveillance System.
Survey and allowed the research team to compare subjective cognitive decline (SCD) measures for current smokers, recent former smokers, and those who had quit years earlier. The analysis included 136,018 people 45 and older, and about 11% reported SCD.
The prevalence of SCD among smokers in the study was almost 1.9 times that of nonsmokers. The prevalence among those who had quit less than 10 years ago was 1.5 times that of nonsmokers. Those who quit more than a decade before the survey had an SCD prevalence just slightly above the nonsmoking group.
"These findings could imply that the time since smoking cessation does matter, and may be linked to cognitive outcomes," Rajczyk said.
The simplicity of SCD, a relatively new measure, could lend itself to wider applications, she said.
"This is a simple assessment that could be easily done routinely, and at younger ages than we typically start to see cognitive declines that rise to the level of a diagnosis of Alzheimer's Disease or dementia," Rajczyk said, adding, "It's not an intensive battery of questions. It's more a personal reflection of your cognitive status to determine if you're feeling like you're not as sharp as you once were."
Many people don't have access to more in-depth screenings, or to specialists -- making potential applications for measuring SCD even greater, she said.
Wing said it's important to note that these self-reported experiences don't amount to a diagnosis, nor do they confirm independently that a person is experiencing a decline out of the normal ageing process. But, he said, they could be a low-cost, simple tool to consider employing more broadly.
Amy Ferketich, a professor of epidemiology at Ohio State, also worked on the study.
Taliban security personnel on a Soviet-era tank ride towards the border, during clashes between Taliban security personnel and Pakistani border forces, in the Spin Boldak district of Kandahar Province on October 15, 2025. (Photo: Getty Images)
Pakistan and Afghanistan agree to an “immediate ceasefire” after talks in Doha.
At least 10 Afghans killed in Pakistani air strikes before the truce.
Both countries to meet again in Istanbul on October 25.
Taliban and Pakistan pledge to respect each other’s sovereignty.
PAKISTAN and Afghanistan have agreed to an “immediate ceasefire” following talks in Doha, after Pakistani air strikes killed at least 10 Afghans and ended an earlier truce.
The two countries have been engaged in heavy border clashes for more than a week, marking their worst fighting since the Taliban returned to power in 2021.
A 48-hour truce had briefly halted the fighting, which has killed dozens of troops and civilians, before it broke down on Friday.
After the talks in Doha, Qatar’s foreign ministry said early on Sunday that “the two sides agreed to an immediate ceasefire and the establishment of mechanisms to consolidate lasting peace and stability between the two countries”.
The ministry added that both sides would hold follow-up meetings in the coming days to ensure the ceasefire remains in place.
Pakistan’s defence minister Khawaja Asif confirmed the agreement and said the two sides would meet again in Istanbul on October 25.
“Terrorism on Pakistani soil conducted from Afghanistan will immediately stop. Both neighbouring countries will respect each other's sovereignty,” Asif posted on social media.
Afghanistan’s spokesperson Zabihullah Mujahid also confirmed the “signing of an agreement”.
“It was decided that both countries will not carry out any acts of hostility against each other,” he wrote on X on Sunday.
“Neither country will undertake any hostile actions against the other, nor will they support groups carrying out attacks against the Government of Pakistan.”
The defence ministers shared a photo on X showing them shaking hands after signing the agreement.
Security tensions
The clashes have centred on security concerns.
Since the Taliban’s return to power, Pakistan has seen a sharp rise in militant attacks, mainly near its 2,600-kilometre border with Afghanistan.
Islamabad claims that groups such as Tehreek-e-Taliban Pakistan (TTP) operate from “sanctuaries” inside Afghanistan, a claim the Taliban government denies.
The recent violence began on October 11, days after explosions in Kabul during a visit by Taliban foreign minister Amir Khan Muttaqi to India.
The Taliban then launched attacks along parts of the southern border, prompting Pakistan to threaten a strong response.
Ahead of the Doha talks, a senior Taliban official told AFP that Pakistan had bombed three areas in Paktika province late Friday, warning that Kabul would retaliate.
A hospital official in Paktika said that 10 civilians, including two children, were killed and 12 others injured in the strikes. Three cricket players were among the dead.
Zabihullah Mujahid said on X that Taliban forces had been ordered to hold fire “to maintain the dignity and integrity of its negotiating team”.
Saadullah Torjan, a minister in Spin Boldak in Afghanistan’s south, said: “For now, the situation is returning to normal.”
“But there is still a state of war, and people are afraid.”
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